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Fatigue is frequently recognized as a systemic sign indicating the presence of anemia due to the decreased oxygen-carrying capacity of the blood. Anemia results in a reduced number of red blood cells or insufficient hemoglobin, which leads to inadequate oxygen delivery to tissues and organs. As a consequence, individuals may experience symptoms such as weakness, fatigue, or a general feeling of lethargy. This systemic manifestation occurs because the body is trying to compensate for the lack of oxygen; increased exertion becomes difficult, leading to the sensation of extreme tiredness.

High blood pressure, increased white blood count, and blurred vision are not typically associated with anemia in the same way. While some conditions related to anemia could lead to changes in blood pressure or white blood count, these are not direct indicators of anemia itself. Fatigue, however, is a primary and well-documented symptom that reflects the underlying issue of diminished red blood cell function and insufficient oxygenation.