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Retinal detachment can occur as a progression of sickle cell retinopathy due to the pathological changes that occur in the retina as a result of sickle cell disease. Sickle cell retinopathy is characterized by the occlusion of retinal blood vessels, leading to ischemia and the subsequent development of neovascularization, or the formation of new blood vessels. These new vessels are fragile and can bleed or cause traction on the retina, ultimately increasing the risk of retinal detachment.

This condition is particularly concerning in the context of sickle cell disease, where the chronic nature of the vascular changes can predispose patients to additional complications as the disease progresses. Although other ocular complications such as myopia, cataracts, and glaucoma may also present in patients with sickle cell disease, retinal detachment is a direct consequence of the retinal changes associated with sickle cell retinopathy and is considered a serious and acute complication that necessitates prompt intervention.